VDBP and VDR Mutations May Cause In-Stent Restenosis

Objective: In-stent restenosis (ISR) is the narrowing of a stented coronary artery lesion. A considerable number patients undergoing percutaneous intervention (PCI) are affected by ISR. The predominant mechanism in development ISR an inflammatory response to vessel wall injury during PCI. Vitamin D reported have anti-inflammatory properties, so it may also be related with Therefore, this study relationship between vitamin receptor (VDR), binding protein (VDBP) gene variations and were investigated. 
 Methods: Fifty-eight who chest pain, underwent angiography found previously inserted stent included patient group thirty-five pain not their previous control group. rs7041 rs4588 VDBP; rs1544410 rs2228570 VDR investigated real-time polymerase chain reaction (RT-PCR). Results evaluated statistically. Results: CC genotype variation CA VDBP statistically high was had myocardial infarction history before implantation. Additionally, demonstrated that deficiency (vitamin level